Help With Autism

Middle Eastern families, sophisticated genetic analysis and groundbreaking neuroscience have implicated a half-dozen new genes in autism research. More importantly, it strongly supports the emerging idea that autism stems from disruptions in the brain’s ability to form new connections in response to experience consistent with autism’s onset during the first year of life, when many of these connections are normally made.

Autism genes have been difficult to identify because the disorder is complex, with a variety of causes stemming from many possible genes or combinations of genes. In addition, since people with autism tend not to have children, most of the genes identified thus far aren’t inherited from a parent, but instead are mutated during embryonic development, making them hard to track through traditional linkage studies in families.

Just over 6 percent of the 88 families showed rare, inherited deletions within DNA regions linked to autism. These affected DNA regions varied among families, further indication of autism’s large variety of genetic causes. In all, the technique identified five chromosome deletions affecting at least six identifiable genes.

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